SPR refers to a phenomenon in which the reflected light disappears at a specific incident angle when light is incident on the side of a prism on which a gold film (about 50 nm) is deposited, and the angle at this time is called the SPR angle. When biomolecules combine on the gold film, the refractive index of the gold film surface changes, and the SPR angle moves according to the refractive index change. The SPR system characterizes intermolecular bonds by acquiring sensorgrams that record changes in the SPR angle in real time.